Medical Books : Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy

Cancer Stem Cells: Novel Concepts & Prospects for Tumor Therapy

Product Details
Book Publisher: Springer (October, 2007)
ISBN: 3540708529
Book author: Otmar D. Wiestler, Bernhard Haendler, Dominik Mumberg

Book Description:
Cancer stem cells werehave originally been identified in leukemia & later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly & have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus prominent into tumor recurrence & metastasis. The recent identification of growth & differentiation pathways responsible for cancer stem cell proliferation & survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer stem cells features great therapeutic opportunities but also offers for major challenges regarding preclinical models, therapeutic windows, & clinical study end points. rapidshare