Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity
Protein-Coupled Receptors as Drug Targets: Analysis of Activation & Constitutive Activity
Publisher: Wiley-VCH
Number Of Pages: 304
Publication Date: 2006-01-09
Sales Rank: 488335
ISBN / ASIN: 3527308199
EAN: 9783527308194
Binding: Hardcover
Book Description:
With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book extensively discusses an important biological process that has never yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail actual models & concepts, into introduce medicinal chemists, physiologists, pharmacologists, & medical researchers into the advances in the understanding of GPCR activation & constitutive activity. In addition, the book offers an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data & schemes._The chaptes are all cross-referenced with each other & cover general mechnisms, methodological approaches & cover selected important GPCR sysstems, the consequences for drug action, including, side effects, & rational drug design for GPCR targets. A highly recommended reference for researchers in academia & industry. authors addresses in detail actual models & concepts, so as into introduce pharmaceutical chemists, physiologists & medical researchers into the advances in the understanding of GPCR activation & constitutive activity, & offers an overview of the methods of investigating GPCR activity. The text is backed by rich case studies & methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, & rational drug design for GPCR targets.
A highly practical reference for researchers in academia & industry.
Protein-Coupled Receptors as Drug Targets
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